Atypical Cushings in Dogs

Atypical Cushing's in dogs refers to a pattern where the adrenal glands produce excessive amounts of certain sex hormones—particularly progesterone, androstenedione, or 17-hydroxyprogesterone—while cortisol levels remain within normal limits. This differs from classical Cushing's syndrome, where cortisol itself is elevated. The condition can produce signs that overlap with typical Cushing's disease, though the hormonal picture is distinct. Owners often arrive at this page because their dog shows signs such as increased thirst and urination, coat changes, or subtle shifts in behaviour or body shape, yet standard tests for Cushing's syndrome have come back normal or inconclusive. Some dogs are identified during investigation of other concerns, particularly when routine bloodwork or imaging suggests adrenal involvement without clear cortisol excess. This page explores the observable signs that may prompt consideration of atypical Cushing's, the underlying hormonal mechanisms that distinguish it from classical disease, the investigations used to identify these patterns, and the range of approaches that exist for managing affected dogs. The condition remains an evolving area within veterinary endocrinology, and clinical understanding continues to develop.