Plasma Cell Pododermatitis in Cats

Plasma cell pododermatitis is an uncommon condition in cats where the footpads become infiltrated with a particular type of immune cell called a plasma cell. The central pad is most often affected, becoming soft, spongy, and visibly swollen. In many cases the surface may take on a smooth or slightly shiny appearance, and some cats develop ulceration or bleeding with time. Owners typically notice that one or more pads look larger or feel different in texture, sometimes described as marshmallow-like or puffy. The cat may or may not show signs of discomfort—some walk normally despite the visible change, while others limp or avoid putting weight on the affected foot. The condition can involve one pad or several, and tends to occur in middle-aged to older cats, though younger animals are sometimes affected. This page explores the signals that may be seen, what is understood about the underlying immune process, how the condition is investigated and confirmed, and the range of approaches used to manage it. The course is variable, and in some cats the changes resolve without intervention, while in others treatment is considered.