SYMPTOM
Seizures
Episodes of involuntary muscle activity, altered consciousness, or collapse lasting seconds to minutes.
Idiopathic Epilepsy
In many dogs and some cats, seizures occur without an identifiable structural or metabolic cause, a condition termed idiopathic epilepsy. This is thought to reflect an inherent predisposition to seizure activity within the brain's electrical circuitry, with certain breeds showing higher prevalence than others. Idiopathic epilepsy typically presents in younger to middle-aged animals and produces recurrent seizures that may follow recognisable patterns in terms of frequency, timing, and character. The diagnosis is generally reached by excluding other identifiable causes of seizure activity. In cats, an underlying structural or metabolic cause has generally been found proportionally more often than in dogs.
Structural Brain Disease
Conditions that physically affect brain tissue, including tumours, inflammatory diseases such as encephalitis, vascular events, congenital malformations, and traumatic injuries, can disrupt normal neuronal function and produce seizure activity. The location, size, and nature of the structural lesion influence the character of the seizures and any accompanying neurological signs. Animals with structural brain disease may show additional neurological abnormalities between seizures, such as changes in behaviour, vision deficits, circling, or head pressing, that reflect the effects of the lesion on surrounding brain tissue.
Metabolic and Systemic
The brain is sensitive to changes in its chemical environment, and metabolic disturbances can lower the seizure threshold sufficiently to produce clinical seizure activity. Hypoglycaemia, hepatic encephalopathy from liver disease, severe electrolyte imbalances, uraemia from kidney failure, and certain endocrine disorders can all affect brain function to the point of triggering seizures. These metabolically driven seizures may occur in association with identifiable systemic illness and may resolve or recur in concert with fluctuations in the underlying metabolic parameter.
Toxic
Numerous substances can produce seizure activity through direct neurotoxic effects or by disrupting normal neurotransmitter function. Sources seen in the UK include slug pellets containing metaldehyde, mouse baits containing alphachloralose, permethrin flea products made for dogs reaching a cat, chocolate, xylitol-sweetened products, blue-green algae in ponds and lakes, human medicines (both prescribed and accidental ingestions), and recreational drugs. Timing varies with the toxin. Signs from blue-green algae can begin within minutes, and those from metaldehyde slug pellets in dogs within 30 minutes to 6 hours, while signs after chocolate usually appear within 6 to 12 hours of it being eaten and in severe cases can last up to 72 hours. A dog flea product on a cat usually causes signs within a few hours but sometimes not until 24 to 72 hours later, and xylitol can lower blood sugar in dogs within 30 minutes or, when it is in some chewing gums, up to 12 to 18 hours later. Early signs are commonly tremors, twitching, agitation or overheating before full seizures, and with several of these toxins the seizures continue or recur until treated. The temporal relationship between potential exposure and seizure onset can be an important diagnostic clue.
Infectious
Infectious agents that reach the central nervous system, including viruses, bacteria, fungi, and protozoa, can produce inflammation within the brain (encephalitis) that may manifest as seizure activity. The specific infectious agents vary by geographic region and the animal's exposure history. Infectious causes of seizures may produce additional signs of systemic illness such as fever, lethargy, and appetite loss, alongside neurological signs, and the seizures may develop in the context of a broader illness rather than appearing in an otherwise healthy-appearing animal.
Reactive
Some seizures occur as a physiological response to a transient insult rather than reflecting chronic brain disease. These reactive seizures may be triggered by acute metabolic crises such as very low blood sugar or calcium, severe overheating, certain medications, or abrupt withdrawal from substances that affect the nervous system. They may occur as isolated events that do not recur once the triggering factor is resolved, or they may indicate a temporary lowering of the seizure threshold that returns to normal once the underlying cause is addressed.
Why timing matters
Early observation
A first seizure is significant regardless of how brief it seemed. In the hours around it, what matters is whether it has stopped, whether the animal is returning to normal awareness, and whether a toxin or metabolic crisis lies behind it, since these causes can bring further seizures within hours. The animal's age at first seizure can provide useful context: onset between about six months and six years of age in dogs fits the pattern of idiopathic epilepsy, while onset in very young animals or in older animals may raise different considerations. The circumstances surrounding the first seizure, the animal's behaviour before and after, the duration and character of the event, and any potential exposure to toxins or recent illness all contribute valuable information. After a typical seizure, a period of confusion, pacing, thirst, hunger or apparent blindness lasting minutes to hours is common. An animal that does not begin to recover, or that has a further seizure before recovering, is in a different and more dangerous situation. Some animals experience a single seizure that never recurs, while for others the first seizure marks the beginning of a recurring pattern.
Later presentation
As seizure activity recurs, the pattern of recurrence becomes an important part of the clinical picture. The frequency of episodes, whether they are increasing or stable, the consistency of seizure character, and the inter-ictal period (the time and behaviour between seizures) all provide information. Some animals develop a recognisable pattern: seizures at consistent intervals, clusters at predictable times, or events triggered by identifiable stimuli. Changes in seizure frequency, duration, or character over time may reflect progression of an underlying condition or may influence management decisions.
The long-term trajectory of seizure disorders varies considerably. Idiopathic epilepsy may remain relatively stable or may show a gradually increasing frequency over years. Structural brain diseases may produce a more consistently progressive course with changing seizure patterns. Metabolic causes may produce seizures that fluctuate with the underlying condition.
Conditions commonly associated
Epilepsy in Dogs
Epilepsy arises from abnormal, excessive electrical activity within the brain, and when this activity spreads across affected regions it produces the sudden involuntary muscle activity, altered consciousness, or collapse seen during a seizure.
Feline Infectious Peritonitis (FIP)
Seizures may occur in the non-effusive (dry) form of FIP when granulomatous inflammation involves the brain, reflecting immune-mediated vasculitis and inflammatory lesion formation within the central nervous system.
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Systemic Hypertension in Cats
Severe hypertension can cause neurological complications including seizures when blood pressure damages brain tissue.
Epilepsy in Cats
Epilepsy in cats can cause seizures ranging from subtle facial twitching to full tonic-clonic convulsions. Feline seizures often look different from those in dogs and may include unusual behavioural changes.
Portosystemic Shunt
Severe accumulation of toxins, particularly ammonia, in portosystemic shunt cases can trigger seizure activity.
Brain Tumours
A tumour growing within the brain can disrupt normal electrical activity, triggering seizures that may be the first sign an owner notices.
Glioma in Dogs
A glioma growing within the brain's tissue can disrupt normal electrical activity, triggering seizures that are often the first sign noticed.
Meningioma
A tumour arising from the tissue lining the brain can irritate underlying nervous tissue. In dogs, seizure activity is often the first sign an owner sees. In cats, a gradual change in behaviour, becoming quieter, less active and less interactive, is more usual, and seizures occur in a minority.
Pituitary Macroadenoma
As the enlarging pituitary mass presses on surrounding brain tissue, it can trigger seizure activity.
Ethylene Glycol Toxicity
Toxic metabolites of ethylene glycol and the resulting drop in blood calcium can trigger seizure activity. The antidote is effective only in the first hours after ingestion, and an early drunken-like phase can appear to pass before kidney failure develops.
Granulomatous Meningoencephalomyelitis (GME)
Inflammatory lesions affecting the brain in this condition can trigger seizure activity depending on where they form.
Hepatic Encephalopathy
Seizures can occur when circulating toxins normally cleared by the liver reach the brain in high enough concentrations.
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Hydrocephalus
Seizures can result from the raised pressure that excess fluid places on the surrounding brain tissue.
Necrotising Meningoencephalitis (NME)
Inflammation of the brain tissue in NME can disrupt normal electrical activity and trigger seizure episodes.
Permethrin Toxicity in Cats
Permethrin, found in some flea products made for dogs, overstimulates the nervous system of cats, causing twitching and tremors that in more severe poisoning progress to seizures, often within hours of exposure.
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Toxoplasmosis
When this parasite affects the brain, it can disrupt normal electrical activity and trigger seizures.
Xylitol Toxicity in Dogs
Severe low blood sugar from xylitol ingestion can leave the brain without enough glucose to function normally, triggering a seizure.
Insulinoma
If blood glucose drops severely, the effect on brain activity can trigger a seizure, which usually settles once glucose levels come back up.
Canine Distemper
Distemper virus can invade the brain, producing seizures that sometimes take the form of rhythmic jaw movements described as chewing-gum fits. Neurological signs usually appear one to three weeks after the initial illness, sometimes at the same time or months later, and sometimes with no earlier illness noticed. It is now uncommon in the UK but still seen in unvaccinated and imported dogs.
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Eclampsia in Dogs
A sharp fall in blood calcium in a nursing bitch, most often in the weeks after whelping, causes restlessness, trembling and stiffness that can progress to seizures over a short period.
Blue-Green Algae Toxicity
Toxins from blue-green algae in ponds, lakes and reservoirs can cause tremors and seizures within minutes to hours of a dog swimming in or drinking affected water, and poisoning is frequently fatal.
Angiostrongylus (Lungworm)
Lungworm infection can disrupt blood clotting, and bleeding within the brain or spinal cord can cause seizures and other neurological signs, sometimes in a dog with little or no cough.
Chocolate Toxicity in Dogs
Theobromine and caffeine in chocolate overstimulate the nervous system and heart, and larger ingestions, particularly of dark chocolate or cocoa, can progress from restlessness and tremors to seizures.
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Diabetes Mellitus in Dogs
An insulin dose that is too high for the animal's needs, or insulin given when food has not been eaten, can drive blood sugar low enough to cause weakness, trembling and seizures.
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Idiopathic Head Tremors
Episodes of rhythmic head bobbing or nodding are often mistaken for seizures, but the dog typically stays alert, responds to its name and can often be distracted out of the episode.
Sick Sinus Syndrome
Pauses in the heart rhythm can cause fainting episodes that are easily mistaken for seizures; they tend to be brief, with the animal going limp and recovering quickly, and a heart cause cannot be excluded from the appearance of the episode alone.
When to explore further
A first seizure cannot be sorted into a harmless or a serious cause at home. Poisoning, low blood sugar, bleeding inside the skull and brain inflammation can all first show as a single seizure, and several of these can produce further seizures within hours. The circumstances around the event, including any access to slug pellets, mouse baits, dog flea products in a cat, human medicines, chocolate or xylitol-sweetened foods, often carry much of the diagnostic information. The animal's age, breed, health history, and the specific character of the seizure all contribute to understanding what the event may represent.
Seizures that increase in frequency, duration, or intensity over time may suggest a progressive underlying process. In an animal with an established seizure pattern, a change such as more frequent episodes, longer recovery periods, or the development of new seizure types can be particularly significant, as it may reflect that progression or a change in how well seizures are controlled.
Cluster seizures, where two or more seizures occur within a 24-hour period, represent a different clinical situation from isolated events separated by weeks or months. Clusters can run on into continuous seizure activity, and whether a cluster is settling or building cannot be judged reliably at home.
Seizures that are accompanied by neurological abnormalities between episodes, such as behaviour changes, vision deficits, circling, head tilting, or altered consciousness, may suggest structural brain disease rather than idiopathic epilepsy. The presence of inter-ictal neurological signs can be an important distinguishing factor.
A seizure occurring in an older animal that has not previously had seizure activity may carry different implications compared with new-onset seizures in a young adult. The age of onset influences the range of likely underlying causes and may guide the investigative approach.
A seizure lasting longer than about five minutes, or seizures following one another without the animal regaining normal awareness in between, is known as status epilepticus. Continuous seizure activity drives body temperature up, deprives the brain of oxygen and can cause lasting brain injury or death, with the risk rising the longer it continues. Once established it is less likely to stop on its own, and control generally depends on anticonvulsant medication given by injection, or by the rectal or nasal route in animals already prescribed it for home use.
Seizures in a diabetic animal receiving insulin, in a very young toy-breed puppy, or in a bitch nursing a litter in the weeks after whelping fit the pattern of low blood sugar or low blood calcium. Both can worsen over a short period. Both usually reverse when corrected promptly, although prolonged, severe low blood sugar can leave lasting brain damage.
Some episodes resemble seizures but have other causes. Fainting (syncope) from a heart rhythm problem or heart disease tends to occur during exercise or excitement, lasts seconds, and the animal usually goes limp and returns to normal within a minute or so, without the prolonged confusion, pacing or apparent blindness that often follows a seizure. Some fainting episodes include brief stiffening, so the two cannot always be separated even on video, and heart-related collapse carries its own risk of sudden death. Head tremors in which the dog stays alert and can be distracted, and twitching or paddling during deep sleep that stops when the animal wakes, are more benign patterns.
A seizure diary recording the date, time and duration of each event, the animal's behaviour before and after, and any possible triggers builds a record that becomes more informative over time. Video recording of seizure events is useful because it captures details of the seizure's character, such as which limbs are involved, whether consciousness appears preserved and the specific movements observed, that can be difficult to describe accurately from memory, particularly given the distress of witnessing a seizure. The time a seizure starts shows whether it has run past about five minutes, one of the two features that define status epilepticus (the other is seizures following one another without the animal regaining normal awareness in between), and seconds feel far longer than they are while watching. Animals do not swallow their tongues during a seizure, and hands near the mouth of a seizing animal are at real risk of being bitten, even by a gentle pet. A quiet, dim, cool space away from stairs, water and sharp edges reduces the risk of injury during and after events.
Last reviewed: 9 October 2026 · Dr Alastair Greenway MRCVS